Being one of the true geniuses of the modern era, Albert Einstein recognized that a useful method for understanding the brain’s role in creativity was to study the brains of highly creative people. He also realized that there would be a great deal of interest in examining his own brain after his death, so he willed that his brain be removed before cremation. However, nearly all of the 240 blocks into which Einstein’s brain was dissected were lost and never analyzed. Thirty years later, the Brodmann’s area 39 portion of Einstein’s brain was analyzed histologically by Marian C. Diamond, PhD, and colleagues. They reported that this area of Einstein’s brain contained a higher proportion of glial cells versus neurons, compared with the brains of control subjects. Assuming that the paucity of cortical neurons was not the result of aging (the control subjects were significantly younger than Einstein at the time of his death), how did the loss of neurons relate to Einstein’s creative genius?