Business leaders tend to raise their eyebrows when they read about parallels between history and modern management—and for good reason. There are undoubtedly many people who offer better leadership lessons than Attila the Hun, and it is unclear whether Alexander the Great can tell us much about business strategy. So it’s with some trepidation that we set forth the premise of this article: that the Italian Renaissance was such an extraordinary period of creativity it can shed light on how to stimulate business innovation.